4 Things to Know about Pterostilbene

While trans-pterostilbene may not sound too familiar, its sources–blueberries and grapes–certainly are. Like its cousin resveratrol, plants produce pterostilbene in response to injury and infection and, like resveratrol, it has a high level of bioavailability and offers similar protective effects. Additionally, research suggests pterostilbene may be more powerful than resveratrol. In fact, combining pterostilbene with resveratrol may pack a potent nutritional punch, helpful for supporting healthy cellular function.

Four Benefits of Pterostilbene

Blueberries are one of the most readily-available sources of pterostilbene and are typically available year round. Wine also contains varying levels of this powerful compound. Here are 4 more reasons to add pterostilbene to your diet.

1. Potent Antioxidant

Experiments suggest pterostilbene has several important benefits. First and foremost, the compound acts as a powerful antioxidant and anti-inflammatory. It also appears to bind to PPAR receptors, stimulating production of the compound. PPAR plays an important role regulating cholesterol and lipids in the blood. One study using animal models reported its success lowering triglycerides. [1] In this respect, trans-pterostilbene may be an important adjunct in the future management of heart disease.

2. Regulates Blood Sugar

Numerous studies have found blueberry consumption, particularly pterostilbene ingestion, stabilizes blood sugar. In one study, 97 adults took a pterostilbene supplement for 12 weeks. At the end of the study, 67% of the participants brought their blood glucose levels under control, with an average drop of 32 mg/dl for fasting blood sugar. [2]

3. Rejuvenates Brain Cells

Improved blood sugar levels combine with antioxidant and anti-inflammatory properties to promote brain health. This activity helps brain cells recover and repair damage, restoring brain function. Multiple studies have demonstrated pterostilbene improves motor function and cognitive abilities in adults suffering from early memory changes and Alzheimer's disease. [3]

4. Like Red Wine, Pterostilbene Promotes Longevity

Trans-pterostilbene is a bioactive chemical which has been shown to reverse cognitive decline, stabilize blood sugar, and reduce inflammation. In vitro and in vivo studies support pterostilbene's therapeutic and preventative effects. The compound also acts as a caloric restriction mimetic, triggering the human body to release biochemicals such as adiponectin which slows aging and promotes healing.

Supplementing with Pterostilbene

To get a higher dose of pterostilbene, you can eat a lot (a lot!) of blueberries, or you could also try a supplement. Most supplements will use trans-pterostilbene for its high bioavailability. Sold in individual formulations, the best overall anti-aging benefits can be found in blends. No known side effects have been observed, although pregnant or expecting mothers and anyone on medications should consult with a doctor.

-Dr. Edward F. Group III, DC, ND, DACBN, DCBCN, DABFM


  1. Cignarella A1, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res. 1996 Dec 1;84(5):311-22.
  2. ICMR. Flexible dose open trial of Vijayasar in cases of newly-diagnosed non-insulin-dependent diabetes mellitus. Indian Council of Medical Research (ICMR), Collaborating …read more

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